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Dokumenttyp:
journal article 
Autor(en):
Hartung, HP; Polman, C; Bertolotto, A; Deisenhammer, F; Giovannoni, G; Havrdova, E; Hemmer, B; Hillert, J; Kappos, L; Kieseier, B; Killestein, J; Malcus, C; Comabella, M; Pachner, A; Schellekens, H; Sellebjerg, F; Selmaj, K; Sorensen, PS 
Titel:
Neutralising antibodies to interferon beta in multiple sclerosis : expert panel report. 
Abstract:
Interferon beta (IFNbeta) therapy for multiple sclerosis (MS) is associated with a potential for the development of neutralising antibodies (NAbs) that negatively affect therapy. Several factors influence the development of NAbs, such as lack of complete sequence homology with the endogenous IFNbeta sequence, frequency of administration, level of dose and formulation of IFNbeta. Taken together, the evidence that NAb status reduces clinical efficacy in MS patients is strong. Standardised assays f...    »
 
Zeitschriftentitel:
J Neurol 
Jahr:
2007 
Band / Volume:
254 
Heft / Issue:
Seitenangaben Beitrag:
827-37 
Sprache:
eng 
Print-ISSN:
0340-5354 
TUM Einrichtung:
Neurologische Klinik und Poliklinik