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Document type:
journal article 
Author(s):
Hartung, HP; Polman, C; Bertolotto, A; Deisenhammer, F; Giovannoni, G; Havrdova, E; Hemmer, B; Hillert, J; Kappos, L; Kieseier, B; Killestein, J; Malcus, C; Comabella, M; Pachner, A; Schellekens, H; Sellebjerg, F; Selmaj, K; Sorensen, PS 
Title:
Neutralising antibodies to interferon beta in multiple sclerosis : expert panel report. 
Abstract:
Interferon beta (IFNbeta) therapy for multiple sclerosis (MS) is associated with a potential for the development of neutralising antibodies (NAbs) that negatively affect therapy. Several factors influence the development of NAbs, such as lack of complete sequence homology with the endogenous IFNbeta sequence, frequency of administration, level of dose and formulation of IFNbeta. Taken together, the evidence that NAb status reduces clinical efficacy in MS patients is strong. Standardised assays f...    »
 
Journal title abbreviation:
J Neurol 
Year:
2007 
Journal volume:
254 
Journal issue:
Pages contribution:
827-37 
Language:
eng 
Print-ISSN:
0340-5354 
TUM Institution:
Neurologische Klinik und Poliklinik