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Dokumenttyp:
journal article 
Autor(en):
Mühlau, M; Weindl, A; Wohlschläger, AM; Gaser, C; Städtler, M; Valet, M; Zimmer, C; Kassubek, J; Peinemann, A 
Titel:
Voxel-based morphometry indicates relative preservation of the limbic prefrontal cortex in early Huntington disease. 
Abstract:
In Huntington disease (HD), both the genetic defect and mutant gene product huntington are known but the exact mechanisms that lead to neuronal loss are poorly understood. Until now, the distribution of tissue loss throughout the brain has been investigated intensively. Here we searched for areas that, antipodal to the striatum, display grey-matter (GM) preservation. We performed high resolution T1-weighted magnetic resonance imaging and voxel-based morphometry in 46 patients in early HD and 46...    »
 
Zeitschriftentitel:
J Neural Transm 
Jahr:
2007 
Band / Volume:
114 
Heft / Issue:
Seitenangaben Beitrag:
367-72 
Sprache:
eng 
Print-ISSN:
0300-9564 
TUM Einrichtung:
Neurologische Klinik und Poliklinik; r Neuroradiologie