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Dokumenttyp:
journal article 
Autor(en):
Hoffmann, D; Meyer, B; Wildner, O 
Titel:
Improved glioblastoma treatment with Ad5/35 fiber chimeric conditionally replicating adenoviruses. 
Abstract:
Adenovirus type 5 (Ad5)-based vectors have been used in clinical trials for glioblastoma treatment, but the capacity of Ad5 to infect human glioma cells was questioned. Seeking to improve the adenovirus transduction, we tested four Ad5-based vectors differing only in their fiber gene on permanent and short-term cultures of glioblastoma cells. A wild-type fiber Ad5 vector (Ad5.Luc) was compared to an RGD integrin-binding motif-containing fiber adenovirus (AdlucRGD) and the two fiber chimeras Ad5/...    »
 
Zeitschriftentitel:
J Gene Med 
Jahr:
2007 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
764-78 
Sprache:
eng 
Print-ISSN:
1099-498X 
TUM Einrichtung:
Neurochirurgische Klinik und Poliklinik