User: Guest  Login
Document type:
journal article 
Author(s):
Hoffmann, D; Meyer, B; Wildner, O 
Title:
Improved glioblastoma treatment with Ad5/35 fiber chimeric conditionally replicating adenoviruses. 
Abstract:
Adenovirus type 5 (Ad5)-based vectors have been used in clinical trials for glioblastoma treatment, but the capacity of Ad5 to infect human glioma cells was questioned. Seeking to improve the adenovirus transduction, we tested four Ad5-based vectors differing only in their fiber gene on permanent and short-term cultures of glioblastoma cells. A wild-type fiber Ad5 vector (Ad5.Luc) was compared to an RGD integrin-binding motif-containing fiber adenovirus (AdlucRGD) and the two fiber chimeras Ad5/...    »
 
Journal title abbreviation:
J Gene Med 
Year:
2007 
Journal volume:
Journal issue:
Pages contribution:
764-78 
Language:
eng 
Print-ISSN:
1099-498X 
TUM Institution:
Neurochirurgische Klinik und Poliklinik