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Document type:
journal article 
Author(s):
Stahl, AR; Wagner, B; Poethko, T; Perutka, M; Wester, HJ; Essler, M; Heemann, U; Schwaiger, M; Lutz, J 
Title:
Renal accumulation of [111In]DOTATOC in rats: influence of inhibitors of the organic ion transport and diuretics. 
Abstract:
AIM: Radiation exposure to the kidney limits therapy with radiometal labelled DOTATOC. This study evaluates the organic anion and cation transport (inhibitors: probenecid and cimetidine/dexamethasone) as well as diuresis (furosemide and mannitol) regarding renal uptake of [(111)In]DOTATOC. METHODS: One hundred eight male Fisher rats were injected with [(111)In]DOTATOC via the tail vein. Prior to activity injection a total of 84 rats underwent injection with probenecid vs. sodium chloride 0.9% (4...    »
 
Journal title abbreviation:
Eur J Nucl Med Mol Imaging 
Year:
2007 
Journal volume:
34 
Journal issue:
12 
Pages contribution:
2129-34 
Language:
eng 
Print-ISSN:
1619-7070 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik; r Nephrologie