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Document type:
journal article 
Author(s):
Fuchs, M; Hermannstädter, C; Hutzler, P; Häcker, G; Haller, F; Höfler, H; Luber, B 
Title:
Deletion of exon 8 increases cisplatin-induced E-cadherin cleavage. 
Abstract:
E-Cadherin-mediated cell-cell adhesion plays a key role in epithelial cell survival and loss of E-cadherin or beta-catenin expression is associated with invasive tumor growth. Somatic E-cadherin mutations have been identified in sporadic diffuse-type gastric carcinoma. Here, we analysed the fate of E-cadherin with an in frame deletion of exon 8 compared to wild-type E-cadherin and the involved signalling events during cisplatin-induced apoptosis. We report that mutant E-cadherin was more readily...    »
 
Journal title abbreviation:
Exp Cell Res 
Year:
2008 
Journal volume:
314 
Journal issue:
Pages contribution:
153-63 
Language:
eng 
Print-ISSN:
0014-4827 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene; r Allgemeine Pathologie und pathologische Anatomie