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Document type:
journal article 
Author(s):
Stemberger, C; Huster, KM; Koffler, M; Anderl, F; Schiemann, M; Wagner, H; Busch, DH 
Title:
A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets. 
Abstract:
Upon first antigen encounter, naive CD8(+) T cells get activated, clonally expand, and can develop into very distinct subsets, such as short-living effector cells or different memory subpopulations. The origin of subset diversification is currently unknown, but qualitative and quantitative differences in early signals received by individual precursor cells have been suggested as a major determinant. We show that transfer of a single antigen-specific naive T cell into a normal recipient mouse all...    »
 
Journal title abbreviation:
Immunity 
Year:
2007 
Journal volume:
27 
Journal issue:
Pages contribution:
985-97 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene