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Document type:
journal article 
Author(s):
Kastenmuller, W; Gasteiger, G; Gronau, JH; Baier, R; Ljapoci, R; Busch, DH; Drexler, I 
Title:
Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination. 
Abstract:
CD8+ T cell responses directed against multiple pathogen-derived epitopes are characterized by defined immunodominance hierarchy patterns. A possible explanation for this phenomenon is that CD8+ T cells of different specificities compete for access to epitopes on antigen-presenting cells, and that the outcome of this so-called cross-competition reflects the number of induced T cells. In our study using a vaccinia virus infection model, we found that T cell cross-competition is highly relevant du...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2007 
Journal volume:
204 
Journal issue:
Pages contribution:
2187-98 
Language:
eng 
Print-ISSN:
0022-1007 
TUM Institution:
r Virologie; r Medizinische Mikrobiologie, Immunologie und Hygiene