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Document type:
journal article 
Author(s):
Lech, M; Garlanda, C; Mantovani, A; Kirschning, CJ; Schlöndorff, D; Anders, HJ 
Title:
Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells. 
Abstract:
Toll-like receptors (TLRs) exist on both myeloid and intrinsic renal cells contributing to the initiation of innate immunity during renal infection with uropathogenic Escherichia coli. Toll-interleukin 1 receptor (IL-1R) (TIR)8/SIGIRR is an orphan receptor of the TLR/IL-1R family, which suppresses TLR signaling of immune cells and is highly expressed in the kidney. Lack of TIR8/SIGIRR is associated with enhanced renal chemokine signaling upon exposure to lipopolysaccharide (LPS). This was becaus...    »
 
Journal title abbreviation:
Kidney Int 
Year:
2007 
Journal volume:
72 
Journal issue:
Pages contribution:
182-92 
Language:
eng 
Print-ISSN:
0085-2538 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene