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Document type:
journal article 
Author(s):
Gamrekelashvili, J; Krüger, C; von Wasielewski, R; Hoffmann, M; Huster, KM; Busch, DH; Manns, MP; Korangy, F; Greten, TF 
Title:
Necrotic tumor cell death in vivo impairs tumor-specific immune responses. 
Abstract:
The manner in which cells die is believed to have a major impact on the nature of immune responses to their released Ags. In this study, we present the first direct analysis of tumor-specific immune responses to in vivo occurring tumor cell death through apoptosis or necrosis. Mice bearing thymidine kinase-transfected tumors were treated either with ganciclovir to induce tumor cell apoptosis in vivo or a vascular targeting agent, ZD6126, to induce tumor cell necrosis in vivo. In contrast to tumo...    »
 
Journal title abbreviation:
J Immunol 
Year:
2007 
Journal volume:
178 
Journal issue:
Pages contribution:
1573-80 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene