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Document type:
journal article 
Author(s):
Weber, A; Paschen, SA; Heger, K; Wilfling, F; Frankenberg, T; Bauerschmitt, H; Seiffert, BM; Kirschnek, S; Wagner, H; Häcker, G 
Title:
BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins. 
Abstract:
Release of apoptogenic proteins such as cytochrome c from mitochondria is regulated by pro- and anti-apoptotic Bcl-2 family proteins, with pro-apoptotic BH3-only proteins activating Bax and Bak. Current models assume that apoptosis induction occurs via the binding and inactivation of anti-apoptotic Bcl-2 proteins by BH3-only proteins or by direct binding to Bax. Here, we analyze apoptosis induction by the BH3-only protein Bim(S). Regulated expression of Bim(S) in epithelial cells was followed by...    »
 
Journal title abbreviation:
J Cell Biol 
Year:
2007 
Journal volume:
177 
Journal issue:
Pages contribution:
625-36 
Language:
eng 
Print-ISSN:
0021-9525 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene