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Document type:
journal article 
Author(s):
Hamm, S; Heit, A; Koffler, M; Huster, KM; Akira, S; Busch, DH; Wagner, H; Bauer, S 
Title:
Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo. 
Abstract:
Single-stranded RNA stimulates immune cells and induces the secretion of pro-inflammatory cytokines and type I IFN. As adjuvant RNA can induce a T(h)2 type of humoral response, however, its potency in the induction of cytotoxic T cells in vivo has not been analyzed. Here we show that immunization with the antigen ovalbumin (OVA) and the adjuvant phosphodiester RNA complexed to the cationic lipid N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP) induced a Toll-like recep...    »
 
Journal title abbreviation:
Int Immunol 
Year:
2007 
Journal volume:
19 
Journal issue:
Pages contribution:
297-304 
Language:
eng 
Print-ISSN:
0953-8178 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene