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Document type:
journal article 
Author(s):
Daubeuf, B; Mathison, J; Spiller, S; Hugues, S; Herren, S; Ferlin, W; Kosco-Vilbois, M; Wagner, H; Kirschning, CJ; Ulevitch, R; Elson, G 
Title:
TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock. 
Abstract:
Overactivation of the immune system upon acute bacterial infection leads to septic shock. Specific bacterial products potently stimulate immune cells via toll-like receptors (TLRs). Gram-negative bacteria induce a predominantly TLR4-driven signal through LPS release. To neutralize LPS signaling in experimental models of sepsis, we generated mAbs toward the TLR4/myeloid differentiation protein-2 (MD-2) complex. The binding properties of an array of selected rat mAbs differed in respect to their s...    »
 
Journal title abbreviation:
J Immunol 
Year:
2007 
Journal volume:
179 
Journal issue:
Pages contribution:
6107-14 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene