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Document type:
journal article 
Author(s):
Klein, M; Schmidt, C; Kastenbauer, S; Paul, R; Kirschning, CJ; Wagner, H; Popp, B; Pfister, HW; Koedel, U 
Title:
MyD88-dependent immune response contributes to hearing loss in experimental pneumococcal meningitis. 
Abstract:
Hearing loss is one of the most common sequelae in survivors of pneumococcal meningitis, affecting up to 26% of them. Here, we established the first mouse model of meningitis-associated hearing loss and investigated the role played by the Toll-like receptor-associated adapter molecule MyD88. C57BL/6 mice were infected intracisternally by Streptococcus pneumoniae. By use of audiometry and histological analysis, cochleae were assessed in uninfected control mice during the acute stage and after rec...    »
 
Journal title abbreviation:
J Infect Dis 
Year:
2007 
Journal volume:
195 
Journal issue:
Pages contribution:
1189-93 
Language:
eng 
Print-ISSN:
0022-1899 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene