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Document type:
journal article 
Author(s):
Aly, S; Laskay, T; Mages, J; Malzan, A; Lang, R; Ehlers, S 
Title:
Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. 
Abstract:
The mechanisms leading to granuloma caseation, a hallmark of tuberculosis (TB) in humans, are poorly understood. Lung histopathology of C57BL/6 (WT) mice 16 weeks after aerosol infection with Mycobacterium avium strain TMC724 is uniquely characterized by centrally necrotizing granulomas, strongly resembling human TB lesions. However, IFN-gamma-deficient (GKO) and IFN-gamma-receptor-deficient (GRKO) mice did not develop granuloma necrosis following M. avium infection. Comparison of differentially...    »
 
Journal title abbreviation:
J Pathol 
Year:
2007 
Journal volume:
212 
Journal issue:
Pages contribution:
295-305 
Language:
eng 
Print-ISSN:
0022-3417 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene