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Dokumenttyp:
journal article 
Autor(en):
Heit, A; Schmitz, F; Haas, T; Busch, DH; Wagner, H 
Titel:
Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity. 
Abstract:
Compared to "live" vaccines, the immunogenicity of "subunit" vaccines based on recombinant antigen (Ag) is poor, presumably because exogenous Ag fails to effectively access the endosomal Ag-processing pathways of Ag-presenting cells (APC). To overcome this limitation, we exploited biodegradable poly(lactic-co-glycolic) microspheres (MP) co-entrapping Ag and Toll-like receptor (TLR) 9 or 7 ligands as an endosomal delivery device. In vitro, microspheres were rapidly phagocytosed by APC and translo...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2007 
Band / Volume:
37 
Heft / Issue:
Seitenangaben Beitrag:
2063-74 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene