User: Guest  Login
Document type:
journal article 
Author(s):
Heit, A; Schmitz, F; Haas, T; Busch, DH; Wagner, H 
Title:
Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity. 
Abstract:
Compared to "live" vaccines, the immunogenicity of "subunit" vaccines based on recombinant antigen (Ag) is poor, presumably because exogenous Ag fails to effectively access the endosomal Ag-processing pathways of Ag-presenting cells (APC). To overcome this limitation, we exploited biodegradable poly(lactic-co-glycolic) microspheres (MP) co-entrapping Ag and Toll-like receptor (TLR) 9 or 7 ligands as an endosomal delivery device. In vitro, microspheres were rapidly phagocytosed by APC and translo...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2007 
Journal volume:
37 
Journal issue:
Pages contribution:
2063-74 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene