User: Guest  Login
Document type:
journal article 
Author(s):
Kaiser-Schulz, G; Heit, A; Quintanilla-Martinez, L; Hammerschmidt, F; Hess, S; Jennen, L; Rezaei, H; Wagner, H; Schätzl, HM 
Title:
Polylactide-coglycolide microspheres co-encapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responses. 
Abstract:
Prion diseases are fatal neurodegenerative diseases that are characterized by the conformational conversion of the normal, mainly alpha-helical cellular prion protein (PrP) into the abnormal beta-sheet-rich infectious isoform (PrP(Sc)). The immune system neither shows reaction against cellular PrP nor PrP(Sc), most likely due to profound self-tolerance. In previous studies, we were able to partly overcome self-tolerance using recombinantly expressed dimeric PrP (tandem PrP (tPrP)), in associatio...    »
 
Journal title abbreviation:
J Immunol 
Year:
2007 
Journal volume:
179 
Journal issue:
Pages contribution:
2797-807 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
r Virologie; r Medizinische Mikrobiologie, Immunologie und Hygiene