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Document type:
journal article 
Author(s):
Buhl, A; Metzger, JH; Heegaard, NH; von Landenberg, P; Fleck, M; Luppa, PB 
Title:
Novel biosensor-based analytic device for the detection of anti-double-stranded DNA antibodies. 
Abstract:
BACKGROUND: Patients with systemic lupus erythematosus (SLE) develop a wide variety of serologic manifestations, including double-stranded DNA autoantibodies (anti-dsDNA). The determination of the potentially pathogenic autoantibodies is diagnostically relevant. METHODS: We developed a novel surface plasmon resonance (SPR) biosensor chip for studies of dsDNA and anti-dsDNA binding. A synthetic oligonucleotide was coupled to biotinylated human transferrin, hybridized with the complementary antist...    »
 
Journal title abbreviation:
Clin Chem 
Year:
2007 
Journal volume:
53 
Journal issue:
Pages contribution:
334-41 
Language:
eng 
Print-ISSN:
0009-9147 
TUM Institution:
r Klinische Chemie und Pathobiochemie