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Document type:
journal article 
Author(s):
Görlach, A; Kietzmann, T 
Title:
Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors. 
Abstract:
Superoxide and its derived reactive oxygen species (ROS) have been considered for a long time to be generated as toxic byproducts of metabolic events. More recently, it has been acknowledged that ROS generated in low amounts are also able to act as signaling molecules in a variety of responses. One of the major pathways regulated by the ambient concentration of oxygen relies on the activity of hypoxia-inducible transcription factors (HIF). Originally described to be only induced and activated un...    »
 
Journal title abbreviation:
Methods Enzymol 
Year:
2007 
Journal volume:
435 
Pages contribution:
421-46 
Language:
eng 
Print-ISSN:
0076-6879 
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler