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Document type:
journal article 
Author(s):
Meyer zum Büschenfelde, C; Feuerstacke, Y; Götze, KS; Scholze, K; Peschel, C 
Title:
GM1 expression of non-Hodgkin's lymphoma determines susceptibility to rituximab treatment. 
Abstract:
Immunotherapy with rituximab alone or in conjunction with chemotherapy has significantly improved the treatment outcome of B-cell lymphoma patients. Nevertheless, a subpopulation of patients does not respond to rituximab. The reason for treatment failure as well as the exact mechanism of action is still uncertain. The function of rituximab has long been associated with the partitioning of CD20 molecules to lipid microdomains. We now show that the extent of CD20 recruitment to lipid rafts correla...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2008 
Journal volume:
68 
Journal issue:
13 
Pages contribution:
5414-22 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
III. Medizinische Klinik und Poliklinik