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Dokumenttyp:
journal article 
Autor(en):
Fanta, S; Sonnenberg, M; Skorta, I; Duyster, J; Miething, C; Aulitzky, WE; van der Kuip, H 
Titel:
Pharmacological inhibition of c-Abl compromises genetic stability and DNA repair in Bcr-Abl-negative cells. 
Abstract:
Imatinib inhibits the kinase activity of Bcr-Abl and is currently the most effective drug for treatment of chronic myeloid leukemia (CML). Imatinib also blocks c-Abl, a physiological tyrosine kinase activated by a variety of stress signals including damaged DNA. We investigated the effect of pharmacological inhibition of c-Abl on the processing of irradiation-induced DNA damage in Bcr-Abl-negative cells. Cell lines and peripheral blood mononuclear cells (PBMCs) from healthy volunteers were treat...    »
 
Zeitschriftentitel:
Oncogene 
Jahr:
2008 
Band / Volume:
27 
Heft / Issue:
31 
Seitenangaben Beitrag:
4380-4 
Sprache:
eng 
Print-ISSN:
0950-9232 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik