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Document type:
journal article 
Author(s):
Fanta, S; Sonnenberg, M; Skorta, I; Duyster, J; Miething, C; Aulitzky, WE; van der Kuip, H 
Title:
Pharmacological inhibition of c-Abl compromises genetic stability and DNA repair in Bcr-Abl-negative cells. 
Abstract:
Imatinib inhibits the kinase activity of Bcr-Abl and is currently the most effective drug for treatment of chronic myeloid leukemia (CML). Imatinib also blocks c-Abl, a physiological tyrosine kinase activated by a variety of stress signals including damaged DNA. We investigated the effect of pharmacological inhibition of c-Abl on the processing of irradiation-induced DNA damage in Bcr-Abl-negative cells. Cell lines and peripheral blood mononuclear cells (PBMCs) from healthy volunteers were treat...    »
 
Journal title abbreviation:
Oncogene 
Year:
2008 
Journal volume:
27 
Journal issue:
31 
Pages contribution:
4380-4 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
III. Medizinische Klinik und Poliklinik