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Document type:
journal article 
Author(s):
McCullar, V; Oostendorp, R; Panoskaltsis-Mortari, A; Yun, G; Lutz, CT; Wagner, JE; Miller, JS 
Title:
Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. 
Abstract:
OBJECTIVE: Human natural killer (NK) cell maturation involves the orderly acquisition of NK cell receptors. Our aim was to understand how stromal interactions and cytokines are important in this developmental process. MATERIALS AND METHODS: Human umbilical cord blood (UCB) CD34(+)/Lin(-)/CD38(-) cells were cultured on two murine stromal cell lines (AFT024 and EL08-1D2) in a switch culture to study NK cell development. RESULTS: When human progenitors were cultured on AFT024 with interleukin (IL)-...    »
 
Journal title abbreviation:
Exp Hematol 
Year:
2008 
Journal volume:
36 
Journal issue:
Pages contribution:
598-608 
Language:
eng 
Print-ISSN:
0301-472X 
TUM Institution:
III. Medizinische Klinik und Poliklinik