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Dokumenttyp:
journal article 
Autor(en):
Rödel, C; Arnold, D; Hipp, M; Liersch, T; Dellas, K; Iesalnieks, I; Hermann, RM; Lordick, F; Hinke, A; Hohenberger, W; Sauer, R 
Titel:
Phase I-II Trial of Cetuximab, Capecitabine, Oxaliplatin, and Radiotherapy as Preoperative Treatment in Rectal Cancer. 
Abstract:
PURPOSE: To evaluate the safety and activity of preoperative radiotherapy (RT) with concurrent cetuximab, capecitabine, and oxaliplatin in rectal cancer patients. PATIENTS AND METHODS: A total of 60 patients with rectal cancer (T3-T4 or N+, M1 allowed) entered the trial at five investigator sites; the data from 58 patients were assessable. Cetuximab was given as an initial dose of 400 mg/m(2) 7 days before the start of RT, and then at 250 mg/m(2) once weekly during RT (50.4 Gy in 28 fractions)....    »
 
Zeitschriftentitel:
Int J Radiat Oncol Biol Phys 
Jahr:
2008 
Band / Volume:
70 
Heft / Issue:
Seitenangaben Beitrag:
1081-6 
Sprache:
eng 
Print-ISSN:
0360-3016 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik