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Dokumenttyp:
journal article 
Autor(en):
Bassermann, F; von Klitzing, C; Illert, AL; Münch, S; Morris, SW; Pagano, M; Peschel, C; Duyster, J 
Titel:
Multisite phosphorylation of nuclear interaction partner of ALK (NIPA) at G2/M involves cyclin B1/Cdk1. 
Abstract:
Nuclear interaction partner of ALK (NIPA) is an F-box-containing protein that defines a nuclear skp1 cullin F-box (SCF)-type ubiquitin E3 ligase (SCFNIPA) implicated in the regulation of mitotic entry. The SCFNIPA complex targets nuclear cyclin B1 for ubiquitination in interphase, whereas phosphorylation of NIPA in late G2 phase and mitosis inactivates the complex to allow for accumulation of cyclin B1. Here, we identify the region of NIPA that mediates binding to its substrate cyclin B1. In add...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2007 
Band / Volume:
282 
Heft / Issue:
22 
Seitenangaben Beitrag:
15965-72 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik