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Dokumenttyp:
journal article 
Autor(en):
McAllister-Lucas, LM; Ruland, J; Siu, K; Jin, X; Gu, S; Kim, DS; Kuffa, P; Kohrt, D; Mak, TW; Nuñez, G; Lucas, PC 
Titel:
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. 
Abstract:
Angiotensin II (Ang II) is a peptide hormone that, like many cytokines, acts as a proinflammatory agent and growth factor. After injury to the liver, the hormone assists in tissue repair by stimulating hepatocytes and hepatic stellate cells to synthesize extracellular matrix proteins and secrete secondary cytokines and by stimulating myofibroblasts to proliferate. However, under conditions of chronic liver injury, all of these effects conspire to promote pathologic liver fibrosis. Much of this e...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2007 
Band / Volume:
104 
Heft / Issue:
Seitenangaben Beitrag:
139-44 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik