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Document type:
journal article 
Author(s):
Misra, RS; Russell, JQ; Koenig, A; Hinshaw-Makepeace, JA; Wen, R; Wang, D; Huo, H; Littman, DR; Ferch, U; Ruland, J; Thome, M; Budd, RC 
Title:
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. 
Abstract:
Humans and mice lacking functional caspase-8 in T cells manifest a profound immunodeficiency syndrome due to defective T cell antigen receptor (TCR)-induced NF-kappaB signaling and proliferation. It is unknown how caspase-8 is activated following T cell stimulation, and what is the caspase-8 substrate(s) that is necessary to initiate T cell cycling. We observe that following TCR ligation, a small portion of total cellular caspase-8 and c-FLIP(L) rapidly migrate to lipid rafts where they associat...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2007 
Journal volume:
282 
Journal issue:
27 
Pages contribution:
19365-74 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
III. Medizinische Klinik und Poliklinik