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Dokumenttyp:
journal article 
Autor(en):
Rueda, D; Gaide, O; Ho, L; Lewkowicz, E; Niedergang, F; Hailfinger, S; Rebeaud, F; Guzzardi, M; Conne, B; Thelen, M; Delon, J; Ferch, U; Mak, TW; Ruland, J; Schwaller, J; Thome, M 
Titel:
Bcl10 controls TCR- and FcgammaR-induced actin polymerization. 
Abstract:
Bcl10 plays an essential role in the adaptive immune response, because Bcl10-deficient lymphocytes show impaired Ag receptor-induced NF-kappaB activation and cytokine production. Bcl10 is a phosphoprotein, but the physiological relevance of this posttranslational modification remains poorly defined. In this study, we report that Bcl10 is rapidly phosphorylated upon activation of human T cells by PMA/ionomycin- or anti-CD3 treatment, and identify Ser(138) as a key residue necessary for Bcl10 phos...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2007 
Band / Volume:
178 
Heft / Issue:
Seitenangaben Beitrag:
4373-84 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik