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Document type:
journal article 
Author(s):
Ertmer, A; Huber, V; Gilch, S; Yoshimori, T; Erfle, V; Duyster, J; Elsässer, HP; Schätzl, HM 
Title:
The anticancer drug imatinib induces cellular autophagy. 
Abstract:
The tyrosine kinase inhibitor imatinib (Gleevec, Novartis Pharmaceuticals Corporation; Basel, Switzerland) is a powerful drug for treatment of chronic myelogenous leukemia (CML) and other malignancies. It selectively targets various tyrosine kinases, thereby leading to growth arrest of respective cancer cells. Given its wide application, it is of high importance to know all related underlying molecular mechanisms. We had previously found that imatinib increases the cellular clearance of intrace...    »
 
Journal title abbreviation:
Leukemia 
Year:
2007 
Journal volume:
21 
Journal issue:
Pages contribution:
936-42 
Language:
eng 
Print-ISSN:
0887-6924 
TUM Institution:
Institut für Virologie ; III. Medizinische Klinik und Poliklinik