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Dokumenttyp:
journal article 
Autor(en):
Ertmer, A; Huber, V; Gilch, S; Yoshimori, T; Erfle, V; Duyster, J; Elsässer, HP; Schätzl, HM 
Titel:
The anticancer drug imatinib induces cellular autophagy. 
Abstract:
The tyrosine kinase inhibitor imatinib (Gleevec, Novartis Pharmaceuticals Corporation; Basel, Switzerland) is a powerful drug for treatment of chronic myelogenous leukemia (CML) and other malignancies. It selectively targets various tyrosine kinases, thereby leading to growth arrest of respective cancer cells. Given its wide application, it is of high importance to know all related underlying molecular mechanisms. We had previously found that imatinib increases the cellular clearance of intrace...    »
 
Zeitschriftentitel:
Leukemia 
Jahr:
2007 
Band / Volume:
21 
Heft / Issue:
Seitenangaben Beitrag:
936-42 
Sprache:
eng 
Print-ISSN:
0887-6924 
TUM Einrichtung:
r Virologie; III. Medizinische Klinik und Poliklinik