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Dokumenttyp:
journal article 
Autor(en):
Klemm, S; Zimmermann, S; Peschel, C; Mak, TW; Ruland, J 
Titel:
Bcl10 and Malt1 control lysophosphatidic acid-induced NF-kappaB activation and cytokine production. 
Abstract:
Lysophosphatidic acid (LPA) is a potent bioactive phospholipid that stimulates a variety of cellular responses by acting on cognate G protein-coupled receptors (GPCRs). There is increasing evidence that LPA signaling reprograms gene expression, but the GPCR-induced pathways connecting LPA receptor stimulation to downstream transcription factors are not well characterized. Here, we identify the adapter proteins Bcl10 and Malt1 as essential mediators of LPA-induced NF-kappaB activation. Both prote...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2007 
Band / Volume:
104 
Heft / Issue:
Seitenangaben Beitrag:
134-8 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik