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Document type:
journal article 
Author(s):
Kancha, RK; Grundler, R; Peschel, C; Duyster, J 
Title:
Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations. 
Abstract:
OBJECTIVE: Activating mutations in FLT3 are known to be a frequent transforming event in acute myeloid leukemia. Small molecule-inhibitor therapy targeting the FLT3 kinase is, therefore, an attractive strategy. FLT3 kinase inhibitors, such as PKC412, have already entered clinical trials. Even though results are encouraging, emergence of primary and secondary resistance does occur in the majority of patients. Thus, it will be crucial to carefully characterize the activity of every single compound...    »
 
Journal title abbreviation:
Exp Hematol 
Year:
2007 
Journal volume:
35 
Journal issue:
10 
Pages contribution:
1522-6 
Language:
eng 
Print-ISSN:
0301-472X 
TUM Institution:
III. Medizinische Klinik und Poliklinik