Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Kancha, RK; Grundler, R; Peschel, C; Duyster, J 
Titel:
Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations. 
Abstract:
OBJECTIVE: Activating mutations in FLT3 are known to be a frequent transforming event in acute myeloid leukemia. Small molecule-inhibitor therapy targeting the FLT3 kinase is, therefore, an attractive strategy. FLT3 kinase inhibitors, such as PKC412, have already entered clinical trials. Even though results are encouraging, emergence of primary and secondary resistance does occur in the majority of patients. Thus, it will be crucial to carefully characterize the activity of every single compound...    »
 
Zeitschriftentitel:
Exp Hematol 
Jahr:
2007 
Band / Volume:
35 
Heft / Issue:
10 
Seitenangaben Beitrag:
1522-6 
Sprache:
eng 
Print-ISSN:
0301-472X 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik