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Document type:
journal article 
Author(s):
Jost, PJ; Weiss, S; Ferch, U; Gross, O; Mak, TW; Peschel, C; Ruland, J 
Title:
Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection. 
Abstract:
During T cell development in the thymus, high-affinity/avidity TCR engagement induces negative selection by apoptosis, while lower affinity/avidity TCR interactions lead to positive selection and survival of thymocytes. Yet, the mechanisms that discriminate between positive and negative selection are not fully understood. One major regulator of survival and apoptosis in lymphoid cells is the transcription factor NF-kappaB. Several reports have indicated key roles for NF-kappaB in positive and ne...    »
 
Journal title abbreviation:
J Immunol 
Year:
2007 
Journal volume:
178 
Journal issue:
Pages contribution:
953-60 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
III. Medizinische Klinik und Poliklinik