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Document type:
journal article 
Author(s):
Oeckinghaus, A; Wegener, E; Welteke, V; Ferch, U; Arslan, SC; Ruland, J; Scheidereit, C; Krappmann, D 
Title:
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. 
Abstract:
Triggering of antigen receptors on lymphocytes is critical for initiating adaptive immune response against pathogens. T-cell receptor (TCR) engagement induces the formation of the Carma1-Bcl10-Malt1 (CBM) complex that is essential for activation of the IkappaB kinase (IKK)/NF-kappaB pathway. However, the molecular mechanisms that link CBM complex formation to IKK activation remain unclear. Here we report that Malt1 is polyubiquitinated upon T-cell activation. Ubiquitin chains on Malt1 provide a...    »
 
Journal title abbreviation:
EMBO J 
Year:
2007 
Journal volume:
26 
Journal issue:
22 
Pages contribution:
4634-45 
Language:
eng 
Print-ISSN:
0261-4189 
TUM Institution:
III. Medizinische Klinik und Poliklinik