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Dokumenttyp:
journal article 
Autor(en):
Oeckinghaus, A; Wegener, E; Welteke, V; Ferch, U; Arslan, SC; Ruland, J; Scheidereit, C; Krappmann, D 
Titel:
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. 
Abstract:
Triggering of antigen receptors on lymphocytes is critical for initiating adaptive immune response against pathogens. T-cell receptor (TCR) engagement induces the formation of the Carma1-Bcl10-Malt1 (CBM) complex that is essential for activation of the IkappaB kinase (IKK)/NF-kappaB pathway. However, the molecular mechanisms that link CBM complex formation to IKK activation remain unclear. Here we report that Malt1 is polyubiquitinated upon T-cell activation. Ubiquitin chains on Malt1 provide a...    »
 
Zeitschriftentitel:
EMBO J 
Jahr:
2007 
Band / Volume:
26 
Heft / Issue:
22 
Seitenangaben Beitrag:
4634-45 
Sprache:
eng 
Print-ISSN:
0261-4189 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik