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Document type:
journal article 
Author(s):
Miething, C; Grundler, R; Mugler, C; Brero, S; Hoepfl, J; Geigl, J; Speicher, MR; Ottmann, O; Peschel, C; Duyster, J 
Title:
Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment. 
Abstract:
The kinase inhibitor imatinib mesylate targeting the oncoprotein Bcr-Abl has revolutionized the treatment of chronic myeloid leukemia (CML). However, even though imatinib successfully controls the leukemia in chronic phase, it seems not to be able to cure the disease, potentially necessitating lifelong treatment with the inhibitor under constant risk of relapse. On a molecular level, the cause of disease persistence is not well understood. Initial studies implied that innate features of primitiv...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2007 
Journal volume:
104 
Journal issue:
11 
Pages contribution:
4594-9 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
III. Medizinische Klinik und Poliklinik