Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Miething, C; Grundler, R; Mugler, C; Brero, S; Hoepfl, J; Geigl, J; Speicher, MR; Ottmann, O; Peschel, C; Duyster, J 
Titel:
Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment. 
Abstract:
The kinase inhibitor imatinib mesylate targeting the oncoprotein Bcr-Abl has revolutionized the treatment of chronic myeloid leukemia (CML). However, even though imatinib successfully controls the leukemia in chronic phase, it seems not to be able to cure the disease, potentially necessitating lifelong treatment with the inhibitor under constant risk of relapse. On a molecular level, the cause of disease persistence is not well understood. Initial studies implied that innate features of primitiv...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2007 
Band / Volume:
104 
Heft / Issue:
11 
Seitenangaben Beitrag:
4594-9 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik