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Dokumenttyp:
journal article 
Autor(en):
Keller, UB; Old, JB; Dorsey, FC; Nilsson, JA; Nilsson, L; MacLean, KH; Chung, L; Yang, C; Spruck, C; Boyd, K; Reed, SI; Cleveland, JL 
Titel:
Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. 
Abstract:
Reduced levels of the cyclin-dependent kinase inhibitor p27(Kip1) connote poor prognosis in cancer. In human Burkitt lymphoma and in precancerous B cells and lymphomas arising in Emu-Myc transgenic mice, p27(Kip1) expression is markedly reduced. We show that the transcription of the Cks1 component of the SCF(Skp2) complex that is necessary for p27(Kip1) ubiquitylation and degradation is induced by Myc. Further, Cks1 expression is elevated in precancerous Emu-Myc B cells, and high levels of Cks1...    »
 
Zeitschriftentitel:
EMBO J 
Jahr:
2007 
Band / Volume:
26 
Heft / Issue:
10 
Seitenangaben Beitrag:
2562-74 
Sprache:
eng 
Print-ISSN:
0261-4189 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik