User: Guest  Login
Document type:
journal article 
Author(s):
Keller, UB; Old, JB; Dorsey, FC; Nilsson, JA; Nilsson, L; MacLean, KH; Chung, L; Yang, C; Spruck, C; Boyd, K; Reed, SI; Cleveland, JL 
Title:
Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. 
Abstract:
Reduced levels of the cyclin-dependent kinase inhibitor p27(Kip1) connote poor prognosis in cancer. In human Burkitt lymphoma and in precancerous B cells and lymphomas arising in Emu-Myc transgenic mice, p27(Kip1) expression is markedly reduced. We show that the transcription of the Cks1 component of the SCF(Skp2) complex that is necessary for p27(Kip1) ubiquitylation and degradation is induced by Myc. Further, Cks1 expression is elevated in precancerous Emu-Myc B cells, and high levels of Cks1...    »
 
Journal title abbreviation:
EMBO J 
Year:
2007 
Journal volume:
26 
Journal issue:
10 
Pages contribution:
2562-74 
Language:
eng 
Print-ISSN:
0261-4189 
TUM Institution:
III. Medizinische Klinik und Poliklinik