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Dokumenttyp:
journal article 
Autor(en):
Scheich, F; Duyster, J; Peschel, C; Bernhard, H 
Titel:
The immunogenicity of Bcr-Abl expressing dendritic cells is dependent on the Bcr-Abl kinase activity and dominated by Bcr-Abl regulated antigens. 
Abstract:
In Ph(+) chronic myeloid leukemia (CML), the constitutively active Bcr-Abl kinase leads to the up-regulation and activation of multiple genes, which may subsequently result in the expression of leukemia-associated antigens. In this study, we investigated the immunogenicity of Bcr-Abl-regulated antigens by stimulating CD8(+) T lymphocytes with autologous dendritic cells transfected with RNA coding for Bcr-Abl wild-type or a kinase-deficient mutant. Significant HLA class I-restricted T-cell respon...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2007 
Band / Volume:
110 
Heft / Issue:
Seitenangaben Beitrag:
2556-60 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik