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Dokumenttyp:
journal article 
Autor(en):
Sargin, B; Choudhary, C; Crosetto, N; Schmidt, MH; Grundler, R; Rensinghoff, M; Thiessen, C; Tickenbrock, L; Schwäble, J; Brandts, C; August, B; Koschmieder, S; Bandi, SR; Duyster, J; Berdel, WE; Müller-Tidow, C; Dikic, I; Serve, H 
Titel:
Flt3-dependent transformation by inactivating c-Cbl mutations in AML. 
Abstract:
In acute myeloid leukemia (AML), mutational activation of the receptor tyrosine kinase (RTK) Flt3 is frequently involved in leukemic transformation. However, little is known about a possible role of highly expressed wild-type Flt3 in AML. The proto-oncogene c-Cbl is an important regulator of RTK signaling, acting through its ubiquitin ligase activity and as a platform for several signaling adaptor molecules. Here, we analyzed the role of c-Cbl in Flt3 signal transduction and myeloid transformati...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2007 
Band / Volume:
110 
Heft / Issue:
Seitenangaben Beitrag:
1004-12 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik