Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Neudorfer, J; Schmidt, B; Huster, KM; Anderl, F; Schiemann, M; Holzapfel, G; Schmidt, T; Germeroth, L; Wagner, H; Peschel, C; Busch, DH; Bernhard, H 
Titel:
Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens. 
Abstract:
The development of MHC/peptide multimers has facilitated the visualization and purification of antigen-specific T cells. However, the persistence of multimers leads to prolonged T cell receptor signaling and subsequently to altered T-cell function. We have recently developed a new type of MHC/peptide multimers, which can be dissociated from the T cell. Herein, we have generated and tested for the first time reversible HLA/peptide multimers, termed Streptamers, for the isolation of human T cells....    »
 
Zeitschriftentitel:
J Immunol Methods 
Jahr:
2007 
Band / Volume:
320 
Heft / Issue:
1-2 
Seitenangaben Beitrag:
119-31 
Sprache:
eng 
Print-ISSN:
0022-1759 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene