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Dokumenttyp:
journal article 
Autor(en):
Krötz, F; Keller, M; Derflinger, S; Schmid, H; Gloe, T; Bassermann, F; Duyster, J; Cohen, CD; Schuhmann, C; Klauss, V; Pohl, U; Stempfle, HU; Sohn, HY 
Titel:
Mycophenolate acid inhibits endothelial NAD(P)H oxidase activity and superoxide formation by a Rac1-dependent mechanism. 
Abstract:
Endothelial dysfunction precedes hypertension and atherosclerosis and predicts cardiac allograft vasculopathy and death in heart transplant recipients. Endothelial overproduction of reactive oxygen species, such as superoxide anions produced by NAD(P)H oxidase, induces endothelial dysfunction. Because immunosuppressive drugs have been associated with increased reactive oxygen species production and endothelial dysfunction, we sought to elucidate the underlying mechanisms. Reactive oxygen species...    »
 
Zeitschriftentitel:
Hypertension 
Jahr:
2007 
Band / Volume:
49 
Heft / Issue:
Seitenangaben Beitrag:
201-8 
Sprache:
eng 
Print-ISSN:
0194-911X 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik