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Dokumenttyp:
journal article 
Autor(en):
Jost, PJ; Ruland, J 
Titel:
Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. 
Abstract:
The transcription factor NF-kappaB is a tightly regulated positive mediator of T- and B-cell development, proliferation, and survival. The controlled activity of NF-kappaB is required for the coordination of physiologic immune responses. However, constitutive NF-kappaB activation can promote continuous lymphocyte proliferation and survival and has recently been recognized as a critical pathogenetic factor in lymphoma. Various molecular events lead to deregulation of NF-kappaB signaling in Hodgki...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2007 
Band / Volume:
109 
Heft / Issue:
Seitenangaben Beitrag:
2700-7 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik