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Document type:
journal article 
Author(s):
Jost, PJ; Ruland, J 
Title:
Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. 
Abstract:
The transcription factor NF-kappaB is a tightly regulated positive mediator of T- and B-cell development, proliferation, and survival. The controlled activity of NF-kappaB is required for the coordination of physiologic immune responses. However, constitutive NF-kappaB activation can promote continuous lymphocyte proliferation and survival and has recently been recognized as a critical pathogenetic factor in lymphoma. Various molecular events lead to deregulation of NF-kappaB signaling in Hodgki...    »
 
Journal title abbreviation:
Blood 
Year:
2007 
Journal volume:
109 
Journal issue:
Pages contribution:
2700-7 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
III. Medizinische Klinik und Poliklinik