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Document type:
journal article 
Author(s):
Reindl, W; Weiss, S; Lehr, HA; Förster, I 
Title:
Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid-specific signal transducer and activator of transcription 3-deficient mice. 
Abstract:
Dysregulated cytokine responsiveness by myeloid cells can be a trigger for the development of chronic inflammation as well as inflammatory bowel disease. Thus, mice with a myeloid-specific defect in signal transducer and activator of transcription (Stat) 3 develop spontaneous colitis secondary to the inability of myeloid cells to respond to the immunosuppressive cytokine interleukin-10. We now examined whether the inflammation caused by Stat3-deficient macrophages is cell autonomous or dependent...    »
 
Journal title abbreviation:
Immunology 
Year:
2007 
Journal volume:
120 
Journal issue:
Pages contribution:
19-27 
Language:
eng 
Print-ISSN:
0019-2805 
TUM Institution:
II. Medizinische Klinik und Poliklinik