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Dokumenttyp:
journal article 
Autor(en):
Kolb, S; Fritsch, R; Saur, D; Reichert, M; Schmid, RM; Schneider, G 
Titel:
HMGA1 controls transcription of insulin receptor to regulate cyclin D1 translation in pancreatic cancer cells. 
Abstract:
The HMGA1 proteins act as architectural transcription factors and are involved in the regulation of genes important in the process of carcinogenesis. Although HMGA1 proteins are overexpressed in most types of cancer, signaling circuits regulated by HMGA1 are not clarified in detail. In this study, we show that HMGA1 proteins promote proliferation of pancreatic cancer cells by accelerating G(1) phase progression. Transfection of HMGA1-specific small interfering RNA (siRNA) activates the RB-depend...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2007 
Band / Volume:
67 
Heft / Issue:
10 
Seitenangaben Beitrag:
4679-86 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik