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Dokumenttyp:
journal article 
Autor(en):
Retzer-Lidl, M; Schmid, RM; Schneider, G 
Titel:
Inhibition of CDK4 impairs proliferation of pancreatic cancer cells and sensitizes towards TRAIL-induced apoptosis via downregulation of survivin. 
Abstract:
Pancreatic ductal adenocarcinoma is one of the most common causes of cancer death in Western countries with an average survival after diagnosis of 3-6 months and a five-year survival rate under 5%. Because of the lack of effective therapies, there is the need to characterize new molecular treatment strategies. Abnormal regulation of the cell cycle is a hallmark of neoplasia. Cyclin-dependent kinase 4 (CDK4), a key regulator of G1-phase of the cell cycle, has been shown to be overexpressed in pan...    »
 
Zeitschriftentitel:
Int J Cancer 
Jahr:
2007 
Band / Volume:
121 
Heft / Issue:
Seitenangaben Beitrag:
66-75 
Sprache:
eng 
Print-ISSN:
0020-7136 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik