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Dokumenttyp:
journal article 
Autor(en):
Schneider, G; Reichert, M; Saur, D; Hamacher, R; Fritsch, R; Schmid, RM 
Titel:
HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2. 
Abstract:
OBJECTIVE: Histone deacetylases (HDACs) have been linked to cell cycle control in various models, involving regulation of the cyclin-dependent kinase inhibitor p27(Kip1). RESULTS: Here, we demonstrate that HDAC inhibition by trichostatin A reduces S-phase kinase-associated protein 2 mRNA and protein abundance. Furthermore, in contrast to HDAC1, recruited to the skp2 promoter in the G(0) phase, HDAC3 is bound in early S phase. Activating function of HDAC3 towards the skp2 gene has been validated...    »
 
Zeitschriftentitel:
Cell Prolif 
Jahr:
2007 
Band / Volume:
40 
Heft / Issue:
Seitenangaben Beitrag:
522-31 
Sprache:
eng 
Print-ISSN:
0960-7722 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik