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Document type:
journal article 
Author(s):
Junt, T; Moseman, EA; Iannacone, M; Massberg, S; Lang, PA; Boes, M; Fink, K; Henrickson, SE; Shayakhmetov, DM; Di Paolo, NC; van Rooijen, N; Mempel, TR; Whelan, SP; von Andrian, UH 
Title:
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. 
Abstract:
Lymph nodes prevent the systemic dissemination of pathogens such as viruses that infect peripheral tissues after penetrating the body's surface barriers. They are also the staging ground of adaptive immune responses to pathogen-derived antigens. It is unclear how virus particles are cleared from afferent lymph and presented to cognate B cells to induce antibody responses. Here we identify a population of CD11b+CD169+MHCII+ macrophages on the floor of the subcapsular sinus (SCS) and in the medull...    »
 
Journal title abbreviation:
Nature 
Year:
2007 
Journal volume:
450 
Journal issue:
7166 
Pages contribution:
110-4 
Language:
eng 
Print-ISSN:
0028-0836 
TUM Institution:
I. Medizinische Klinik und Poliklinik