Login
- Document type:
- Journal Article; Article
- Author(s):
- Schömig, K; Ndrepepa, G; Mehilli, J; Pache, J; Kastrati, A; Schömig, A
- Title:
- Thoracic radiotherapy in patients with lymphoma and restenosis after coronary stent placement.
- Abstract:
- OBJECTIVES: The aim of this study was to assess the incidence of restenosis after coronary stenting in patients with lymphoma treated with thoracic radiation. BACKGROUND: Patients with Hodgkin lymphoma treated with thoracic radiation have an increased incidence of coronary artery disease (CAD). The incidence of restenosis after percutaneous coronary interventions is completely unknown. METHODS: This study included 12,626 consecutive patients with CAD treated with coronary stenting during a 10-year period. Within this cohort, three subgroups of patients were assessed: patients with lymphoma and previous thoracic radiation (15 patients), patients with lymphoma without thoracic radiation (7 patients) and patients without lymphoma or previous thoracic radiation (control group; 12,604 patients). Coronary stenting was performed after a median [25th; 75th percentiles] of 8 years [4; 17] after thoracic radiation. The primary end point of the study was restenosis at 6-month coronary angiography. RESULTS: Six-month coronary angiography was performed in 14 patients (93%) in the group with lymphoma and radiation, 6 patients (86%) in the group with lymphoma without radiation and 10,032 patients (80%) in the control group (P = 0.38). Angiographic restenosis was found in 12 patients (85.7%) in the group with lymphoma and radiation, 1 patient (16.7%) in the group with lymphoma without radiation and 2,555 patients (25.5%) in the control group (P < 0.001). Multiple logistic regression identified thoracic radiation as an independent predictor of coronary restenosis (odds ratio 21.7, 95% confidence interval, 4.7-100.9, P < 0.001). CONCLUSIONS: Patients with lymphoma treated with thoracic radiation have an increased risk of restenosis after coronary artery stenting.
- Journal title abbreviation:
- Catheter Cardiovasc Interv
- Year:
- 2007
- Journal volume:
- 70
- Journal issue:
- 3
- Pages contribution:
- 359-65
- Language:
- eng
- Fulltext / DOI:
- doi:10.1002/ccd.21109
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/17722039
- Print-ISSN:
- 1522-1946
- TUM Institution:
- I. Medizinische Klinik und Poliklinik (Kardiologie)
BibTeX