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Dokumenttyp:
journal article 
Autor(en):
Junt, T; Schulze, H; Chen, Z; Massberg, S; Goerge, T; Krueger, A; Wagner, DD; Graf, T; Italiano, JE; Shivdasani, RA; von Andrian, UH 
Titel:
Dynamic visualization of thrombopoiesis within bone marrow. 
Abstract:
Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood. Here we describe the use of multiphoton intravital microscopy in intact BM to visualize platelet generation in mice. MKs were observed as sessile cells that extended dynamic proplatelet-like protrusions into microvessels. These intravascular extensions appeared to be sheared from their transendothelial stems by flowing blood, resulting in the appearance of proplatelets in...    »
 
Zeitschriftentitel:
Science 
Jahr:
2007 
Band / Volume:
317 
Heft / Issue:
5845 
Seitenangaben Beitrag:
1767-70 
Sprache:
eng 
Print-ISSN:
0036-8075 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik