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Document type:
journal article 
Author(s):
Junt, T; Schulze, H; Chen, Z; Massberg, S; Goerge, T; Krueger, A; Wagner, DD; Graf, T; Italiano, JE; Shivdasani, RA; von Andrian, UH 
Title:
Dynamic visualization of thrombopoiesis within bone marrow. 
Abstract:
Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood. Here we describe the use of multiphoton intravital microscopy in intact BM to visualize platelet generation in mice. MKs were observed as sessile cells that extended dynamic proplatelet-like protrusions into microvessels. These intravascular extensions appeared to be sheared from their transendothelial stems by flowing blood, resulting in the appearance of proplatelets in...    »
 
Journal title abbreviation:
Science 
Year:
2007 
Journal volume:
317 
Journal issue:
5845 
Pages contribution:
1767-70 
Language:
eng 
Print-ISSN:
0036-8075 
TUM Institution:
I. Medizinische Klinik und Poliklinik