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Document type:
journal article 
Author(s):
Antl, M; von Brühl, ML; Eiglsperger, C; Werner, M; Konrad, I; Kocher, T; Wilm, M; Hofmann, F; Massberg, S; Schlossmann, J 
Title:
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. 
Abstract:
Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis, the major complication of atherosclerosis triggering myocardial infarction and stroke. A central regulatory pathway conveying inhibition of platelet activation/aggregation is nitric oxide (NO)/cyclic GMP (cGMP) signaling by cGMP-dependent protein kinase I (cGKI). However, the regulatory cascade downstream of cGKI mediating platelet inhibition is still unclear. Here, we show that the inositol-1...    »
 
Journal title abbreviation:
Blood 
Year:
2007 
Journal volume:
109 
Journal issue:
Pages contribution:
552-9 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
r Pharmakologie und Toxikologie; I. Medizinische Klinik und Poliklinik