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Document type:
journal article 
Author(s):
Seitz, I; Hess, S; Schulz, H; Eckl, R; Busch, G; Montens, HP; Brandl, R; Seidl, S; Schömig, A; Ott, I 
Title:
Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis. 
Abstract:
OBJECTIVE: The serine protease MT-SP1/matriptase plays an important role in cell migration and matrix degradation. Hepatocyte growth factor (HGF), urokinase-type plasminogen activator (uPA), and protease-activated receptor 2 (PAR-2) have been identified as in vitro substrates of MT-SP1/matriptase. Because PAR-2 is expressed in endothelial cells and contributes to inflammatory processes, we sought to investigate the effects of MT-SP1/matriptase on endothelial cytokine expression and analyzed MT-S...    »
 
Journal title abbreviation:
Arterioscler Thromb Vasc Biol 
Year:
2007 
Journal volume:
27 
Journal issue:
Pages contribution:
769-75 
Language:
eng 
Print-ISSN:
1079-5642 
TUM Institution:
I. Medizinische Klinik und Poliklinik; chirurgie; r Allgemeine Pathologie und pathologische Anatomie