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Document type:
journal article 
Author(s):
Schäfer, A; Schulz, C; Fraccarollo, D; Tas, P; Leutke, M; Eigenthaler, M; Seidl, S; Heider, P; Ertl, G; Massberg, S; Bauersachs, J 
Title:
The CX3C chemokine fractalkine induces vascular dysfunction by generation of superoxide anions. 
Abstract:
OBJECTIVE: The chemokine fractalkine activates platelets and induces leukocyte adhesion to the endothelium. Expression of fractalkine and its receptor, CX3CR1, is elevated in coronary artery disease. We assessed the effects of fractalkine on vascular function in isolated rat aorta. METHODS AND RESULTS: CX3CR1 expression was demonstrated in rat aortic endothelial and smooth muscle cells by immunohistochemistry, Western blot, and polymerase chain reaction (PCR). Fractalkine (up to 1 microg/mL) did...    »
 
Journal title abbreviation:
Arterioscler Thromb Vasc Biol 
Year:
2007 
Journal volume:
27 
Journal issue:
Pages contribution:
55-62 
Language:
eng 
Print-ISSN:
1079-5642 
TUM Institution:
I. Medizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie; chirurgie